The toxin affects the part of the brain known as the hippocampus and causes rapid deterioration. Affected sea lions exhibit head weaving, bobbing, bulging from the eyes, mucus from the mouth, disorientation and sometimes seizures. The sick sea lions are almost always female, and are often pregnant. Unfortunately, not much can be done for the affected sea lions. Treatment typically consists of injecting approximately 4 liters of an electrolyte solution containing vitamin B-12 to flush out the toxin. The mammals are also given medication to control seizures. The survival rate is only about 25% to 50%.
Sea lion pups can also strand on the coast for other reasons. In 2015 a very large number of sea lion strandings were reported along the California coast. These sea lions were typically very emaciated and dehydrated, indicating a lack of food and/or a premature separation from their mothers. There is speculation that the warmer-than-normal ocean temperatures during the 2014-2015 winter caused schools of anchovies and sardines to migrate further offshore, making it more difficult for the sea lions to find food. More on this in a Thank You Ocean video.
If you see a sea lion in distress, it's important that you don't go near, touch or feed the animal. You should contact a lifeguard or a marine mammal care center. Here are the facilities in California:
North Coast Marine Mammal Center in Crescent City
Marine Mammal Center in Sausalito
Santa Barbara Marine Mammal Center
Channel Islands Marine and Wildlife Institute
California Wildlife Center in Malibu (Santa Monica Mountains)
Marine Animal Rescue in Los Angeles (El Segundo)
Fort MacArthur Marine Mammal Center in San Pedro
Pacific Marine Mammal Center in Laguna Beach
Sea World in San Diego
Domoic Acid Poisoning (NOAA Fisheries)
Domoic Acid Toxicity (Marine Mammal Center)
Unfortunately, domoic acid is not the only health threat out there and sea lions are not the only marine species affected. Sea otters, dolphins and other marine life are also being affected by pollutants and infectious agents that run off the land into the ocean. Here's a National Geographic article that discusses this issue and specific health threats.